Point mutation

A point mutation, or single base substitution, is a type of mutation that causes the replacement of a single base nucleotide with another nucleotide. One can categorize point mutations as follows:transitions: replacement of a purine base with another purine or replacement of a pyrimidine with another pyrimidinetransversions: replacement of a purine with a pyrimidine or vice versa.
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Noun
1. a mutation due to an intramolecular reorganization of a gene
(synonym) gene mutation
(hypernym) mutation, genetic mutation, chromosomal mutation

A single nucleotide base change in the DNA, as for example in sickle cell disease.

A single nucleotide change in the DNA sequence. Even if it is in the coding region of a gene, it may or may not change the amino acid sequence. The rates of point mutation for MHC genes are not unusually high. The extensive polymorphism results from their accumulation over many millions of years of transspecies evolution.

B: (Biologi) mutasi titik
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