Paget's disease, otherwise known as osteitis deformans, is a chronic disorder that typically results in enlarged and deformed bones. It is named after Sir
James Paget, the British surgeon who first described this disease. The excessive breakdown and formation of bone tissue that occurs with Paget's disease can cause bone to weaken, resulting in bone pain,
arthritis, deformities, and fractures. Paget's disease may be caused by a
slow virus infection (i.e.,
paramyxoviruses such as
measles and
respiratory syncytial virus), present for many years before symptoms appear. There is also a hereditary factor since the disease may appear in more than one family member.
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A chronic condition in which both the breakdown and regrowth of bone are increased. Paget's disease of bone occurs most frequently in the pelvic and leg bones, skull, and lower spine. It is most common in older individuals, and may lead to bone pain, deformities, and fractures. Also called osteitis deformans.
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