An open reading frame or ORF is a portion of an organism's genome which contains a sequence of bases that could potentially
encode a protein. The start and stop ends of the ORF are not equivalent to the ends of the mRNA, but they are usually contained within the mRNA. In a
gene, ORFs are located between the start-code sequence (initiation
codon) and the stop-code sequence (termination codon). ORFs are usually encountered when sifting through pieces of
DNA while trying to locate a
gene. Since there exist variations in the start-code sequence of organisms with altered genetic code, the ORF will be identified differently. A typical ORF finder will employ algorithms based on existing
genetic codes (including the altered ones) and all possible reading frames.
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(genetics) An open reading frame in DNA has no termination codon, no signal to stop reading the nucleotide sequence, and so may be translated into protein.
(ORF): A nucleotide sequence encoding a polypeptide starting with a start and ending with a stop codon.
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