Oy vey
A combination of "Oy gevalt" and "Vey is mir". An expression of exasperation, i.e., "What now?!" or "Oh, no!"
Vey is mire
Cry of agony, distress, misery, pain; (int.) oh!, oh boy!; ow!, ouch!woe is me!; I am pain itself!
Commentary:
The most melodramatic expression of suffering, used to describe everyday miseries such as shaving nicks, sinus headaches or acid indigestion. A favorite expression of kvetches and yentas, often preceded by "oy".