Nephrosis

n. degenerative disease of the kidneys (Pathology)

Not to be confused with nephritic syndrome Nephrotic syndrome is a disorder where the kidneys have been damaged, causing them to leak protein from the blood into the urine. It is characterised by proteinuria (>3.5g/ day) hypoalbuminemia, hyperlipidemia and edema. The most common sign is excess fluid in the body. This may take several forms:Puffiness around the eyes, characteristically in the morning.Edema over the legs which is pitting (i.e. leaves a little pit when the fluid is pressed out, which resolves over a few seconds). Fluid in the pleural cavity causing pleural effusion.Fluid in the peritoneal cavity causing ascites. Hypertension (rarely)Some patients may notice foamy urine, due to a lowering of the surface tension by the severe proteinuria. Actual urinary complaints such as hematuria or oliguria are uncommon, and are seen commonly in nephritic syndrome.May have features of underlying cause, such rash associated with SLE, or neuropathy with diabetes.Examination should also exclude other causes of gross edema- especially the cardiovascular and hepatic system.
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Nephrosis /ne·phro·sis/ [Gr.] any kidney disease characterized by purely degenerative lesions of the renal tubules. [more]Nephrosis - Community and Resources

Noun
1. a syndrome characterized by edema and large amounts of protein in the urine and usually increased blood cholesterol; usually associated with glomerulonephritis or with a complication of various systemic diseases
(synonym) nephrotic syndrome
(hypernym) syndrome
2. a disease affecting the kidneys
(synonym) kidney disease, renal disorder, nephropathy
(hypernym) uropathy
(hyponym) nephritis, Bright's disease

Non-inflammatory, non-neoplastic disease of the kidney.