Mitotic crossover is a rare type of genetic recombination that may occur in some types of somatic cells during mitosis. Mitotic crossover may occur in organisms that do not have a cycle of sexual reproduction where chromosomal crossover would normally occur during meiosis to generate genetic variation. It can only occur in diploid cells and a pair of chromosomes is required for the crossover to occur.
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During mitosis sister chromatids freely exchange material without changing anything in genetic material because they are identical. Very rarely, and by chance, homologous chromosomes come very close to each other and exchange material as in meiosis which results in a recombinant chromosome.
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