Malaise

n. weakness or general discomfort caused by an illness; feeling of unease, uneasiness

Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling, often the first indication of an infection or other disease. Often defined in medicinal research as a "general feeling of being unwell".Colloquially, malaise has been referred to as "the creeping crud" (especially in reference to the malaise caused by communicable diseases such as influenza and the common cold). This usage may have originated in folk medicine, but it is adopted from the French word meaning "discomfort," "feeling faint," "feeling sick."
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Malaise /mal·aise/ a vague feeling of discomfort. mal·aise n. A vague feeling of bodily discomfort, as at the beginning of an illness. [more]Malaise - Community and Resources

Noun
1. physical discomfort (as mild sickness or depression)
(synonym) unease, uneasiness
(hypernym) discomfort, uncomfortableness

n. (new spell.=Maläse) mishap, unlucky accident, misfortune, contretemps