The acronym MSH may stand for one of several things, including:

• Markham Stouffville Hospital - A hospital in Markham, Ontario
• Marvel Super Heroes - an acronym commonly used by comic, arcade game and role-playing fans.
• Maxwell's Silver Hammer - a song by The Beatles
• Melanocyte-stimulating hormone - a hormone produced in the pituitary gland, and related to skin pigmentation.
• Mississippi State Hospital - a mental hospital in Rankin County, Mississippi
• Monad Shell — a former name for the Microsoft Windows PowerShell
• Mossley Hill railway station, England; National Rail station code MSH.
• Mount St. Helens, in the United States is often abbreviated as MSH.
• Mount Sinai Hospital (Toronto) - a University of Toronto affiliated hospital.
• Fulton County Charter High School of Mathematics and Science - a former charter school in Georgia (U.S. state) also known as Math/Science High.
• Mycothiol, an unusual thiol that is found in Actinobacteria.

Windows PowerShell is Microsoft's task automation framework, consisting of a command-line shell and associated scripting language built on top of, and integrated with the .NET Framework. PowerShell provides full access to COM and WMI, enabling administrators to perform administrative tasks on both local and remote Windows systems.