MAFA (Mast cell function-associated antigen) is a type II receptor that was first identified on the surface of rat mucosal-type
mast cells of the RBL-2H3 line. More recently, human and mouse homologues of MAFA have been discovered yet also (or only) expressed by
NK and
T-cells. The intracellular domain of MAFA contains a single
immunoreceptor tyrosine-based inhibitory motif (ITIM), which clasifies MAFA as a member of an inhibitory receptor superfamily. The inhibitory capacity of MAFA is best defined in mast cells, where MAFA keeps in check the
antigen-induced (i.e. Fc epsilon RI-induced) secretion of inflammatory mediators.
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