Knock down

cause to fall over; defeat

struck down; defeated; taken apart

For knockdowns in combat sports, see Knockout. A gene knockdown is either a genetically modified organism that carries one or more genes in its chromosomes that has been made less active or had its "expression" reduced or is the use of a reagent such as a short DNA or RNA (oligonucleotide) with sequence complementary to an active gene or its mRNA transcript. This oligonucleotide will bind to this active gene (or its transcripts) to decrease expression of a specific gene, copying the effects of such a genetic modification. So far such organisms have been engineered chiefly for research purposes. Also known as knockdown organisms or simply knockdowns, their most direct use is for learning about a gene that has been sequenced, but has an unknown or incompletely known function, an experimental approach known as reverse genetics. Researchers draw inferences from how the knockdown differs from individuals in which the gene of interest has not been made inoperative. Knockdown includes the processes of modifying an organism (as described above) or of using a reagent to suppress gene expression, as in "knocking down a gene."
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KO redirects here. For other uses, see Ko. For other uses of knockout, see Knockout (disambiguation). A knockout (also referred to as a K.O.) is a winning criterion in several full-contact combat sports, such as boxing, kickboxing, Muay Thai, mixed martial arts and others sports involving striking. A knockout is usually awarded when one participant is unable to rise from the canvas within a specified period of time, typically because of fatigue, injury (serious or temporarily incapacitating, e.g. a bleeding cut above the eye can blind a fighter), loss of balance or unconsciousness A technical knockout (also referred to as a T.K.O.) is often declared when the referee or other judges (such as official ring physician, the fighter himself, or the fighter's cornermen) decide that a fighter cannot continue the match, even though he did not fail the count. British records refer to TKOs as either "retired", if the fighter refuses to continue, or "R.S.F.", for Referee Stopped Fight.
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Verb
1. cause to come or go down; "The policeman downed the heavily armed suspect"; "The mugger knocked down the old lady after she refused to hand over her wallet"
(synonym) down, cut down, push down, pull down
(hypernym) strike
(hyponym) submarine
2. knock down with force; "He decked his opponent"
(synonym) deck, coldcock, dump, floor
(hypernym) beat
(derivation) knockdown

Adjective
1. strong enough to knock down or overwhelm; "a knock-down blow"
(synonym) knock-down(a), powerful
(similar) strong

n. knockdown

n.
کاري ہاتھ
knock-down argument
دليل قاطع