Kallmann's Syndrome

Kallmann syndrome is an example of hypogonadism (decreased functioning of the sex hormone-producing glands) caused by a deficiency of gonadotropin-releasing hormone (GnRH), which is created by the hypothalamus. Kallmann syndrome is also known as hypothalamic hypogonadism, familial hypogonadism with anosmia, or hypogonadotropic hypogonadism, reflecting its disease mechanism.
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This syndrome which is an isolated gonadotrophin deficiency(LHRH or LH/FSH) is also known as hypogonadotrophic hypogonadism. It is often assosiated with decreased or absent sense of smell (anosmia), sometimes with other bony (cleft palate), renal and cerebral abnormalities (e.g. colour blindness). It is often familial and is usually X-linked. Management is that of secondary hypogonadism.fertility is possible.