Kupffer cells, also known as Browicz-Kupffer cells or stellate cells, are specialized
macrophages located in the
liver that form part of the
reticuloendothelial system (aka: mononuclear phagocyte system). The cells were first observed by
Karl Wilhelm von Kupffer in 1876. The scientist called them "sternzellen" (star cells or stellate cells) but thought falsely that they were an integral part of the
endothelium of the liver blood vessels and that they originated from it. In
1898, after several years of research, Tadeusz Browicz identified them correctly as macrophages.
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