The Italian Wars, often referred to as the Great Italian Wars or the Great Wars of Italy in historical works, were a series of conflicts from 1494 to 1559 that involved, at various times, all the major states of western Europe (
France,
Spain, the
Holy Roman Empire,
England,
Scotland, the
Republic of Venice, the
Papal States, and most of the
city-states of Italy) as well as the
Ottoman Empire. Originally arising from dynastic disputes over the
Duchy of Milan and the
Kingdom of Naples, the wars rapidly became a general struggle for power and territory among their various participants, and were marked with an increasing degree of alliances, counter-alliances, and regular betrayals.
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