Integrase inhibitors are a class of
antiretroviral drug developed for the treatment of
HIV infection, although they are not necessarily limited to HIV treatment. They block the action of
integrase, an enzyme that integrates genetic material from the virus into its target cell. The US
FDA approved the first,
Raltegravir, brand name
Isentress, on October 12, 2007. Integrase Inhibitors may be taken in combination with other types of HIV drugs to minimize adaptation by the virus. They are also necessary for people whose virus has become immune to current treatments, called
salvage therapy.
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