Gentamicin is an
aminoglycoside antibiotic, and can treat many types of
bacterial infections, particularly
Gram-negative infection. However, gentamicin is not used for
Neisseria gonorrheae,
Neisseria meningitidis or
Legionella pneumophila infections.Gentamicin is a
bactericidal antibiotic that works by binding the 30S subunit of the bacterial
ribosome, interrupting protein synthesis.Like all aminoglycosides, when gentamicin is given orally, it is not effective. This is because it is absorbed from the
small intestine, and then travels through the
portal vein to the
liver, where it is inactivated. Therefore, it can only be given
intravenously,
intramuscularly or
topically.
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