gp120 is a
glycoprotein exposed on the surface of the
HIV envelope. The 120 in its name comes from its
molecular weight of 120 kilodaltons.The crystal structure of gp120 complexed to D1D2 CD4 and a neutralizing antibody Fab was solved by Peter Kwong in 1998. It is organized with an outer domain, an inner domain with respect to its termini and a
bridging sheet. The gp120 gene is around 1.5Kb long and codes for around 500 amino acids. Three copies of gp120 form into a trimer that caps the end of
gp41.
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