Federal University of Santa Catarina (in Portuguese Universidade Federal de Santa Catarina, UFSC) is a public university in Florianópolis, the capital city of Santa Catarina in southern Brazil. Ranked as the 4th best overall university in Latin America by the Webometrics Ranking of World Universities, it is one of the leading Latin-American research universities, being the third largest university in Brazil and the fifth in Latin America, noted for its engineering school, and the only Federal University in the state of Santa Catarina. UFSC is internationally known for the quality of its courses in mechanical engineering, control engineering, Sanitary engineering, electrical engineering and dentistry.

L'université fédérale de Santa Catarina (Universidade Federal de Santa Catarina ou UFSC) est une université fédérale brésilienne située principalement à Florianópolis, capitale de l'État de Santa Catarina.