A fusion inhibitor is a class of
antiretroviral drugs used to treat viral infections such as
HIV. It works by blocking the virus from fusing with a
cell's membrane to
enter and infect the cell.Enfuvirtide
Enfuvirtide, also called T-20, is a fusion inhibitor with the trade name Fuzeon®. For example, HIV binds to host cell receptor
CD4 by the protein
gp120. Upon binding GP120 deforms allowing the viral protein
gp41 to embed itself into the host cell's plasma membrane, entry inhibitors bind to GP41 preventing the creation of an entry pore for the
capsid of the virus keeping it out of the cell.
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