EPITOPE

An epitope is the part of a macromolecule that is recognized by the immune system, specifically by antibodies, B cells, or T cells. Although epitopes are usually thought to be derived from nonself proteins, sequences derived from the host that can be recognized are also classified as epitopes.Most epitopes recognized by antibodies or B cells can be thought of as three-dimensional surface features of an antigen molecule; these features fit precisely and thus bind to antibodies. The part of an antibody that recognizes the epitope is called a paratope. Exceptions are linear epitopes, which are determined by the amino acid sequence (the primary structure) rather than by the 3D shape (tertiary structure) of a protein.
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[EP-i-tope]
A part of a molecule that an antibody will recognize and bind to.

functions as an antigenic determinant a short, linear peptide sequence cut from a larger protein antigen by an antigen-presenting cell and carried to the lymph node to trigger a specific immune response. (see: dendrite)

B: (Kimia) epitop
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