In
analytical chemistry, the detection limit, lower limit of detection, or LOD (limit of detection), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) within a stated
confidence limit (generally 1%). The detection limit is estimated from the
mean of the blank, the
standard deviation of the blank and some confidence factor. Another consideration that affects the detection limit is the accuracy of the model used to predict concentration from the raw analytical signal.
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The lowest concentration of a chemical that can reliably be distinguished from a zero concentration.
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