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Drug resistance is the reduction in effectiveness of a drug such as an antimicrobial or an antineoplastic in curing a disease or condition. When the drug is not intended to kill or inhibit a pathogen, then the term is equivalent to dosage failure or drug tolerance. More commonly, the term is used in the context of resistance acquired by pathogens. When an organism is resistant to more than one drug, it is said to be multidrug-resistant. In a broad sense the immune system of an organism is such a drug delivery system, albeit autonomous, and faces the same arms race problems as external drug delivery.
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The ability of bacteria and other microorganisms to withstand a drug to which they were once sensitive (and were once stalled or killed outright).
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The failure of cancer cells, viruses, or bacteria to respond to a drug used to kill or weaken them. The cells, viruses, or bacteria may be resistant to the drug at the beginning of treatment, or may become resistant after being exposed to the drug.
A Service of the National Cancer Institute.
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[Biol Med] resistencia a los fármacos
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