DIC may refer to:

• Differential interference contrast microscopy, an illumination technique in optical microscopy
• Diisopropylcarbodiimide, a reagent in organic chemistry
• Digital Integrating Computer, a digital implementation of a Differential Analyzer
• Digital image correlation for ultra accurate measurements of deformations, displacement and strain from digital images
• Dissolved inorganic carbon, the sum of inorganic carbon species in a solution
• Deviance information criterion, a diagnostic statistic used in Bayesian model selection
• Dicyclic group

DIC Entertainment (pronounced "deek", rendered "DiC") was an international film and television production company. In addition to animated (and occasionally live-action) television shows such as Ulysses 31 (1981), Inspector Gadget (1983–1986), The Littles (1983), The Real Ghostbusters (1986–1991), Captain Planet and the Planeteers (1990-1993), and the first two seasons of the English adaptation of Sailor Moon (1995–1998), DIC produced live-action feature films while under Disney, including 1998's Meet the Deedles and 1999's Inspector Gadget.