Clinical depression

Clinical depression (also called major-depressive disorder, or unipolar depression when compared to bipolar disorder) is a common mood disorder in psychology and psychiatry, in which a person's enjoyment of life and ability to function socially and in day to day matters is disrupted by intense sadness, melancholia, numbness, or despair.
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Clinical depression n. See depression. clinical depression Psychiatry Persistent sadness or loss of interest in activities for = 2 wks in absence [more]Clinical depression - Community and Resources

Noun
1. a state of depression and anhedonia so severe as to require clinical intervention
(synonym) depressive disorder, depression
(hypernym) affective disorder, major affective disorder, emotional disorder, emotional disturbance
(hyponym) agitated depression