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Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) (trade name Cisplatin,brand name Platin marketed by Cadila Healthcare according to FDA Orange Book) is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
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|NCI Dictionary of Cancer Terms||Download this dictionary|
An anticancer drug that belongs to the family of drugs called platinum compounds.
A Service of the National Cancer Institute.
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