Cirrhosis is a consequence of chronic
liver disease characterized by replacement of liver
tissue by fibrotic
scar tissue as well as regenerative
nodules, leading to progressive loss of liver function. Cirrhosis is most commonly caused by
alcoholism and
hepatitis C, but has many other possible causes.
Ascites (fluid retention in the abdominal cavity) is the most common complication of cirrhosis and is associated with a poor quality of life, increased risk of infection, and a poor long-term outcome. Other potentially life-threatening complications are
hepatic encephalopathy (confusion and coma) and bleeding from
esophageal varices. Cirrhosis is generally irreversible once it occurs, and treatment generally focuses on preventing progression and complications. In advanced stages of cirrhosis the only option is a
liver transplant.
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