Chromatographic response function

Chromatographic response function, often abbreviated to CRF is a coefficient which characterize the quality of the separation in quantitative manner.The CRFs concept have been created during the development of separation optimization, to compare many simulated or real chromatographic separations and to choose best of them. Until now, there are many CRFs proposed and discussed.In HPLC the CRF is calculated from various parameters of the peaks of solutes (like width, retention time, symmetry etc.) are considered into the calculation. In TLC the CRFs are based on the placement of the spots, measured as RF values.
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