Centric fusion

Fusion of the long arms of two acrocentric chromosomes [13,14,15,21,22] into a single chromosome having lost the short arms at the same time. Most often occurs as 21/21, 13/14, and 14/21 translocations. Apart from being an important cause of uniparental disomy, it may cause trisomy 21 (Down's syndrome) in the offspring. Human chromosome 2 is a result of a centric fusion between two ancestral ape chromosomes (gorillas have 24 pairs of chromosomes).

B: (Biologi) fusi sentrik
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