Angioedema

Angioedema (BE: angiooedema), also known by its eponym Quincke's edema, is the rapid swelling (edema) of the skin, mucosa and submucosal tissues. Apart from the common form, mediated by allergy, it has been reported as a side effect of some medications, specifically ACE inhibitors. Additionally, there is an autosomal dominant inherited form, due to mutations in the SERPING1 gene, which results in deficiency of the blood protein C1-inhibitor. This form is called hereditary angioedema (HAE) or occasionally by the outdated term "hereditary angioneurotic edema" (HANE). In this condition, the swelling may also occur in the digestive tract and other organs.
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Angioedema /an·gio·ede·ma/ a vascular reaction involving the deep dermis or subcutaneous or submucosal tissues, representing localized edema caused [more]Angioedema - Community and Resources

Like hives but affects deeper skin layer.

A genetic form of angioedema. (Angioedema is also referred to as Quinke’s disease.) Persons with it are born lacking an inhibitor protein (called C1 esterase inhibitor) that normally prevents activation of a cascade of proteins leading to the swelling of angioedema. Patients can develop recurrent attacks of swollen tissues, pain in the abdomen, and swelling of the voice box (larynx) which can compromise breathing. The diagnosis is suspected with a history of recurrent angioedema. It is confirmed by finding abnormally low levels of C1 esterase inhibitor in the blood. Treatment options include antihistamines and male steroids (androgens) that can also prevent the recurrent attacks. Also called hereditary angioneurotic edema.

Swelling of the skin or mucous membrane and underlying tissue.