Agnogenic myeloid metaplasia

Myelofibrosis with myeloid metaplasia, also known as agnogenic myeloid metaplasia, chronic idiopathic myelofibrosis, and primary myelofibrosis, was first described in 1879 and is currently classified as a myeloproliferative disease caused by the growth and proliferation of an abnormal bone marrow stem cell, resulting in the replacement of the bone marrow with fibrous connective tissue. An eponym for the disease is Heuck-Assmann disease, or Assmann's Disease.
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Agnogenic myeloid metaplasia Myelofibrosis with myeloid metaplasia Hematology A chronic progressive condition–panmyelosis and variable BM [more]Agnogenic myeloid metaplasia - Community and Resources

A progressive, chronic disease in which the bone marrow is replaced by fibrous tissue and blood is made in organs such as the liver and the spleen, instead of in the bone marrow. This disease is marked by an enlarged spleen and progressive anemia. Also called chronic idiopathic myelofibrosis, primary myelofibrosis, myelosclerosis with myeloid metaplasia, and idiopathic myelofibrosis.