Affliction

n. suffering, pain, torment

An affliction is something which causes someone physical, mental, or emotional suffering.Affliction is a title of several works of fiction: FilmsAffliction (1997 film), a 1997 film based on the 1989 novel by Russell Banks.Television"Affliction (Enterprise episode)", a fourth season episode of Star Trek: Enterprise.
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Noun
1. a state of great suffering and distress due to adversity
(hypernym) adversity, hardship, hard knocks
(hyponym) cross, crown of thorns
(derivation) afflict
2. a condition of suffering or distress due to ill health
(hypernym) ill health, unhealthiness, health problem
(hyponym) deformity, malformation, misshapenness
(derivation) afflict, trouble, ail, pain
3. a cause of great suffering and distress
(hypernym) trouble
(hyponym) calvary, martyrdom
(derivation) afflict

n. affliction, desperation; infliction; sorrow, worry

(n.)
The state of being afflicted; a state of pain, distress, or grief.
  

(n.)
The cause of continued pain of body or mind, as sickness, losses, etc.; an instance of grievous distress; a pain or grief.