Urokinase (Abbokinase), also called urokinase-type Plasminogen Activator (uPA), is a
serine protease . Urokinase was originally isolated from human
urine, but is present in several physiological locations, such as blood stream and the
extracellular matrix. The primary physiological substrate is
plasminogen, which is an inactive
zymogen form of the serine protease
plasmin. Activation of plasmin triggers a proteolysis cascade which, depending on the physiological environment participate in
thrombolysis or
extracellular matrix degradation. This links urokinase to vascular diseases and cancer.
See more at Wikipedia.org...
Free Download Now!
