A plague on both your houses

Meaning
Frustrated curse on both sides of an argument.
Origin
From Shakespeare's Romeo and Juliet.
MERCUTIO I am hurt.
A plague o' both your houses! I am sped.
Is he gone, and hath nothing?
Shakespeare was fond of the word plague and used it hundreds of times in the plays. Surprisingly, as the Bible is the other most promiment source of phrases that have entered the English language, there isn't a single reference to it in his plays..