A&E is an abbreviation that may refer to:

• "A&E" (song), a song by Goldfrapp
• A+E, an album by Graham Coxon
• A&E (TV channel), an American cable and satellite television network
• A&E Television Networks, the parent company of the A&E Network
• A&E Records, a record label
• Accident and emergency, a common name in the UK and Ireland for the emergency department of a hospital
• Admiralty and Ecclesiastical Cases, one of the eleven original series of the Law Reports
• Adult and elderly, a type of specialized nursing care
• Always and Everyone, an ITV television series set in the accident and emergency department of a hospital
• Apple & Eve
• Application and experience, a means of knowledge acquisition as distinguished from research under laboratory conditions
• Arts and entertainment, in multimedia

An emergency department (ED), also known as accident & emergency (A&E), emergency room (ER), or casualty department is a medical treatment facility specialising in acute care of patients who present without prior appointment, either by their own means or by ambulance. The emergency department is usually found in a hospital or other primary care center.