The five prime untranslated region (5' UTR), also known as the leader sequence, is a particular section of
messenger RNA (mRNA) and the DNA that codes for it. It starts at the +1 position (where
transcription begins) and ends just before the
start codon (usually AUG) of the
coding region. It usually contains a
ribosome binding site (RBS), in
bacteria also known as the
Shine-Delgarno sequence (AGGAGGU). The 5' UTR may be a hundred or more nucleotides long, and the 3' UTR may be even longer (up to several kilobases in length) (Molecular Cell Biology, 5th edition, Lodish et al. p113, chapter 4.2).
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The short sequence between the transcription initiation site and the start of translation that is retained in mRNA but not translated. It contains the ribosomal binding site (leader sequence) and signal sequence.
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